General Information: AdvaCare is a GMP manufacturer of Pyrantel Pamoate Oral Paste. IvpraCare is a broad-spectrum anti-nematode drug used for the removal and control of mature infections of The following parasites of horses are sensitive to the antiparasitic effects of Intermectin Duo Paste: - Adult tapeworms: Anoplocephala perfoliata. - Large strongyles: Strongylus vulgaris (adults and arterial larval stages), S. edentatus (adults and tissue larval stages), S. equinus (adults), Triodontophorus spp. (adults) and Craterostomum acuticaudatum (adults). - Adult and immature (intraluminal fourth-stage) larvae of small strongyles or cyathostomes, including benzimidazole-resistant strains: Coronocyclus, Cyathostomum, Cylicocyclus, Cylicodontophorus, Cylicostephanus, Parapoteriostomum, Petrovinema and Poteriostomum spp. - Adult hairworms: Trichostrongylus axei. - Adult and immature (fourth stage larvae) pinworms: Oxyuris equi. - Adult, third- and fourth-stage larvae of roundworms (ascarids): Parascaris equorum. - Microfilariae of neck threadworms: Onchocerca spp. - Adult intestinal threadworms: Strongyloides westeri. - Adult large-mouth stomach worms: Habronema muscae. - Oral and, gastric stages of bots: Gasterophilus spp. - Adult and immature (inhibited fourth stage larvae) lungworms: Dictyocaulus arnfieldi. IvpraCare Paste is administered orally at the recommended dose rate of 0.2 mg ivermectin and 1 mg praziquantel per kg bodyweight, corresponding to 1.29 g of paste per 100 kg bodyweight in a single administration. Each applicator, containing 7.74 g of paste, delivers 120 mg ivermectin and 600 mg praziquantel, which is sufficient to treat 600 kg of bodyweight. Make sure the horse’s mouth contains no feed. Insert the syringe into the horse’s mouth at the interdental space. Deposit the medication on the base of the tongue. Raise the horse’s head for a few seconds immediately after application. Side Effects: Some horses carrying heavy infections of Onchocerca microfilariae have experienced oedema and pruritus after administration, probably caused by the death of large numbers of microfilariae. These signs resolve within a few days, but symptomatic treatment may be recommendable. In cases of heavy infestations with tapeworms, signs of mild, transient colic and loose stool may be observed. There have been rare reports of swelling and irritation of the mouth, lip and tongue, and of salivation following administration of Intermectin Duo Paste. These reactions have been transitory in nature, appearing within 1 hour and abating within 24 to 48 hours following administration.   Precautions: Usage in seriously weak animals should be done with caution. Due to similarity of the mechanism of action, the toxicity may be enhanced when PyraCare is used together with methimazole or levamisole consisting of drugs. Adverse reactions will be strengthened when combined with organophosphorus or ethylamine. PyraCare has antagonistic effects with piperazine and cannot be used at the same time. Do not use horses intended for human consumption.